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Drosophila melanogaster wing disc immuno stained for membrane markers
Drosophila pupal wing disc showing an XZ cross section with nuclei in magenta and the membranes in green
Drosophila melanogaster wing disc

Welcome to the
Tissue Mechanics Lab

We are interested in understanding the complex three-dimensional architecture of tissues during development, homeostasis and regeneration. Our focus is on discovering how tissues achieve their correct size and shape, and how to use this knowledge to improve human health.

The genetic and biochemical control of tissue growth, homeostasis and regeneration has been extensively studied over the last century, but it is still unclear how the physical and mechanical properties of cells and tissues contribute to how organs are formed and sculpted. What is clear is that in order to change the three-dimensional architecture of any structure, there must be forces, external and/or internal, acting on the system.

We use an interdisciplinary approach, combining Drosophila and mammalian systems, genetics, live imaging, machine learning image analysis, experimental biophysics, engineering and computational modelling, to understand the importance of mechanical forces in controlling tissue growth, homeostasis and regeneration and how these forces in turn influence gene expression and signalling pathways.

Our work involves using state-of-the-art imaging techniques, molecular biology and computational tools to study tissue development and regeneration in different model organisms. Our team of expert researchers are dedicated to advancing the field of tissue mechanics through cutting-edge research and innovative techniques.


  • Medical Research Council

  • Wellcome

  • UCL Excellence Fellowship

  • European Commission Horizon 2020

  • Lister Institute

  • EMBO Young Investigator Programme

  • L'Oreal UNESCO

  • Leverhulme Trust

  • NC3R


  • Cytoskeleton and cell cortex

  • Polarity and cell shape

  • Signalling pathways

  • Cell-cell interactions

  • Physics of biological systems

  • Tissue growth and morphogenesis

  • Tissue repair and regeneration


  • Light microscopy

  • Electron microscopy

  • Computational modeling

  • Experimental biophysics

  • Machine learning 

  • Image analysis

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